Generation of all carbon quaternary stereocenters at the C-3 carbon of piperidinones and pyrrolidinones and its application in natural product total synthesis

Methodologies regarding the construction of an all carbon quaternary stereocenters at C-3 of lactams have posed significant challenges in the total synthesis of natural products. This review summarizes the advancements for the construction of an all carbon quaternary stereocenters at C-3 of piperidinones and pyrrolidinones and its application in the total synthesis of biologically active and architecturally complex alkaloids. (C) 2018 Elsevier Ltd. All rights reserved.