期刊
TETRAHEDRON
卷 74, 期 38, 页码 5222-5231出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2018.04.058
关键词
Ugi-smiles; Pyrimidines; Sulfone; Suzuki reaction
资金
- ENSTAParistech
- Ministry of higher education and scientific research of Algeria
The Ugi-Smiles reaction of S-benzyl thiouracil have been exploited in several three-step sequences for the preparation of aminopyrimidine libraries with high diversity. After the 4-component coupling, oxidation of the thioether to sulfone is followed by displacement of the latter by various carbon-centered nucleophiles (cyanide, malonate, boronic acids) or amines. The efficiency of the whole sequence was further demonstrated with one-pot procedures. (C) 2018 Published by Elsevier Ltd.
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