A novel electrochemical sensor based on Fe3O4-doped nanoporous carbon for simultaneous determination of diethylstilbestrol and 17β-estradiol in toner

In this paper, Fe3O4-doped nanoporous carbon (Fe3O4-NC) was synthesized through the carbonization of Feporous coordination polymer (Fe-PCP), which are also known as metal-organic framework (MOF), and fabricated into an electrochemical sensor for simultaneous analysis of diethylstilbestrol (DES) and 17 beta-estradiol (E2) in toner. Fe3O4-NC was characterized by scanning electron microscope (SEM), powder X-ray diffraction (pXRD), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, N-2 adsorption-desorption and so on. It is of great practical significance to achieve the simultaneous determination of the two estrogens because estrogens are coexisting in many real samples. The simultaneous determination of two common estrogens, DES and E2, was achieved through electro-catalytically oxidization at a Fe3O4-NC modified glassy carbon electrode (Fe(3)O4-NC/ GCE). The peak currents of DES and E2 increased linearly as their concentrations increasing from 0.01 to 12 mu mol/L and from 0.01 to 20 nmol/L, with detection limits of 4.6 nmol/L and 4.9 nmol/L (S/N = 3), respectively. This work was focused on the simultaneous determination of the two estrogens in toner. Furthermore, the recoveries of DES and E2 were 91.2-110%, in actual toner samples. The experimental results manifest that the sensor with a stronger anti-interference ability can be used for the simultaneous detection of DES and E2 in the actual toner sample.