Sensitive determination of baicalein based on functionalized graphene loaded RuO2 nanoparticles modified glassy carbon electrode

The nanocomposite of ruthenium oxide (RuO2) loaded on Poly-(dimethyldiallylammonium chloride) (PDDA) functionalized reduced graphene oxide (RuO2-PDDA-rGO) was synthesized based on a one-step method. Based on the RuO2-PDDA-rGO modified glassy carbon electrode (GCE), a new electrochemical sensor (RuO2-PDDA-rGO/GCE) was fabricated and used in detection of baicalein for the first time. Compared with other reported electrochemical sensors for the detection of baicalein, the prepared RuO2-PDDA-rGO/GCE had a wider linear range (2-400 nM) and lower detection limit (0.6 nM, S/N = 3). The other advantages were the excellent repeatability of proposed method and good stability of prepared sensor.