期刊
TALANTA
卷 183, 期 -, 页码 39-47出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2018.02.009
关键词
Carbon dots; Green luminescence; Macroscopic preparation; Fluorescent nanoprobe; Identifying cancer cells
资金
- National Natural Science Foundation of China [21475080, 21575084]
- Shanxi Scholarship Council of China [2017-K1]
- Hundred Talent Programme of Shanxi Province
Early diagnosis is pivotal in subsequent prognosis and treatment of cancer. Herein, folic acid-conjugated carbon dots (FA-CDs) as a fluorescent nanoprobe were fabricated for identifying cancer cells visually. Green luminescent carbon dots (CDs) from active dry yeast (ADY) were readily prepared in scale-up to reach macroscopic production with a high yield of 50% via a facile and rapid microwave approach. The as-prepared CDs were further combined with folic acid (FA) by covalent bonding to fabricate the FA-CDs for identification of cancer cells over expressing folate receptor (FR). Experimental outcomes demonstrated that the resultant FA-CDs noninvasively entered into cancer cells via receptor-mediated endocytosis and could differentiate FR-positive HepG2 cells from a cell mixture by fluorescence imaging, which suggests a promising prospect of the FA-CDs as an efficient probe for cancer diagnosis and succeeding personalized therapy.
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