期刊
TALANTA
卷 179, 期 -, 页码 641-645出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2017.11.065
关键词
Self-assembly; Multiple catalyzed hairpin assembly; DNA nanoparticles; Colorimetric detection
资金
- National Natural Science Foundation of China [21377089, 21407109, 21475091]
It is known that DNA molecules can be used to build a various of complicated geometrical DNA nanostructures with programmable sequence design, and these DNA nanomaterials show a promising application in biotechnology and biomedicine. However, the construction of large-sized three dimensional DNA-based nanomaterials still remains a challenge. In this work, we propose a new strategy that only employs one target DNA to trigger multiple catalyzed hairpin assembly (CHA) reactions and sticky ends self-assembly to prepare hundreds of nanometer-sized DNA nanoparticles. Moreover, the obtained DNA nanoparticles can be served as efficient biosensors for sensitive colorimetric nucleic acids detection with a detection limit of 7.7 pM
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