期刊
TALANTA
卷 179, 期 -, 页码 9-14出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2017.10.038
关键词
Paper-based test strip; SERS; Whole blood; Mucin-1; Au NPs
资金
- National Natural Science Foundation of China [21327902, 21535003, 21675081]
- State Key Laboratory of Analytical Chemistry for Life Science [5431ZZXM1611]
- Fundamental Research Funds for the Central Universities [020514380101]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
A paper-based SERS test strip combining strengths of paper chip and Raman active substrate was demonstrated to overcome challenges in spectroscopic sensing of complicated samples and realize quantitative detection of disease markers in whole blood. The precisely controlled Au NPs were not only capable of generating condensed hot spots on the fibers, but also enhanced the size exclusion effect of paper, resulting in the novel performance on both SERS detection and sample pretreatment. A biosensor for Mucin-1 is developed by equipping the Au NPs with aptamer. Combining all these merits, this small, cheap and portable test strip might find wide application in clinical diagnosis and health evaluation.
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