期刊
TALANTA
卷 181, 期 -, 页码 340-345出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2018.01.038
关键词
Au NPs-polydopamine-polyvinylidene fluoride membrane chips; Probe; Enrichment; SALDI-TOF MS
资金
- National Basic Research Program of China [2015CB931903]
- National Natural Science Foundation of China [21537004, 21477140, 21621064, 21777169]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB14010201]
High-throughput and rapid detection of hazardous compounds in complicated samples is essential for the solution of environmental problems. We have prepared a pH-paper-like chip which can rapidly indicate the occurrence of organic contaminants just through dipping the chip in water samples for short time followed by fast analysis with surface-assisted laser desorption/ionization time-of-flight mass spectrometry (SALDI-TOF MS). The chips are composed of polyvinylidene fluoride membrane (PVDFM), polydopamine (PDA) film and Au nanoparticles (Au NPs), which are layer-by-layer assembled according to the adhesion, self-polymerization and reduction property of dopamine. In the Au NPs loaded polydopamine-polyvinylidene fluoride membrane (Au NPs-PDA-PVDFM) chips, PVDFM combined with PDA film are responsible for the enrichment of organic analyte through hydrophobic interactions and pi-pi stacking; Au NPs serve as effective SALDI matrix for the rapid detection of target analyte. After dipping into water solution for minutes, the Au-PDA-PVDFM chips with enriched organic analytes can be detected directly with SALDI-TOF MS. The good solid-phase extraction performance of the PDA-PVDFM components, remarkable matrix effect of the loaded AuNPs, and sensitivity of the SALDI-TOF MS technique ensure excellent sensitivity and reproducibility for the quantification of trace levels of organic contaminants in environmental water samples.
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