期刊
SYNTHESIS-STUTTGART
卷 50, 期 14, 页码 2741-2752出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0037-1610129
关键词
multicomponent reactions; C-C coupling; cyclocondensation; alkynes; heterocycles; palladium
资金
- Fonds der Chemischen Industrie
A novel consecutive three-component synthesis of -pyrones is based upon an alkynylation-Michael addition-cyclocondensation (AMAC) sequence, starting from (hetero)aroyl chloride and terminal alkyne to furnish the alkynone which reacts with malonates to give the -pyrones in moderate to very good yields. By concatenating ammonolysis of the -pyrones, an alkynylation-Michael addition-cyclocondensation-ammonolysis (AMACA) synthesis of -pyridones can be conceived. -Pyridone products with and without ester functionality are obtained in moderate yields.
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