期刊
NATURE REVIEWS CANCER
卷 12, 期 11, 页码 753-766出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3371
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资金
- Research Foundation Flanders, Belgium (FWO) [3G064307, G059710, 3G0B7912W]
Intracellular signalling cascades initiated by class III receptor tyrosine kinases (RTK-IIIs) and their cytokine ligands contribute to haematopoiesis and mesenchymal tissue development. They are also implicated in a wide range of inflammatory disorders and cancers. Recent snapshots of RTK-III ectodomains in complex with cognate cytokines have revealed timely insights into the structural determinants of RTK-III activation, evolution and pathology. Importantly, candidate 'driver' and 'passenger' mutations that have been identified in RTK-IIIs can now be collectively mapped for the first time to structural scaffolds of the corresponding RTK-III ectodomains. Such insights will generate a renewed interest in dissecting the mechanistic effects of such mutations and their therapeutic relevance.
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