期刊
SYNLETT
卷 29, 期 9, 页码 1131-1135出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1591948
关键词
fluorine-18; sydnone; bioorthogonal chemistry; fluoroarene; peptide labeling
资金
- Jonsson Comprehensive Cancer Center
- Crump Institute for Molecular Imaging
- NIH [R01GM109078]
- FRQNT
Preparation of [F-18]fluoroarenes with nucleophilic [F-18]fluoride for positron emission tomography (PET) molecular imaging research is a challenging chemical endeavor. Advances in radiofluorination have soared in the last decade, broadening the availability of potential [F-18]fluoroarenes. In this Synpacts article, we highlight the recent development from our laboratory of a practical radiofluorination of anilines via N-arylsydnone intermediates to afford [F-18]fluoroarenes. Further, we emphasize the utility of this methodology towards peptide labeling applications by preparing an F-18-labeled neuropeptide. 1 Introduction 2 Nucleophilic Radiofluorination of N-Arylsydnones 3 Substrate Scope and Applications 4 Conclusion
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据