期刊
SYNLETT
卷 29, 期 8, 页码 1024-1027出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0037-1609302
关键词
Huisgen's 1,4-dipole; N-heterocycles; acetylenic esters; spiro compounds; thiouracil
The reaction of isoquinoline or quinoline with dialkyl acetylenedicarboxylates in the presence of alkyl 2-{3,5-dioxo-5H-thiazolo[ 3,2-a] pyrimidin-2(3H)-ylidene} acetates (generated in situ from acetylenedicarboxylates and 2-thiouracils) led to dialkyl 2-(2-alkoxy-2oxoethylidene)- 5-oxo-2H, 5H, 11b' H-spiro{thiazolo[3,2-a] pyrimidine3,2'-[ 1,3] oxazino[2,3-a] isoquinoline}-3', 4'-dicarboxylates or dialkyl 2(2-alkoxy-2-oxoethylidene)-5-oxo-2H, 4a' H, 5H-spiro{thiazolo[3,2-a] pyrimidine- 3,2'-[1,3] oxazino[3,2-a] quinoline}-1', 2'-dicarboxylates in good yields. The structure of the target compounds was confirmed by X-ray diffraction study.
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