期刊
GEROPSYCH-THE JOURNAL OF GERONTOPSYCHOLOGY AND GERIATRIC PSYCHIATRY
卷 25, 期 4, 页码 235-245出版社
HOGREFE AG-HOGREFE AG SUISSE
DOI: 10.1024/1662-9647/a000074
关键词
BrainAGE; Alzheimer's disease; mild cognitive impairment; structural MRI; pattern recognition
资金
- BMBF [01EV0709, 01GW0740]
We recently proposed a novel method that aggregates the multidimensional aging pattern across the brain to a single value. This method proved to provide stable and reliable estimates of brain aging - even across different scanners. While investigating longitudinal changes in BrainAGE in about 400 elderly subjects, we discovered that patients with Alzheimer's disease and subjects who had converted toADwithin 3 years showed accelerated brain atrophy by + 6 years at baseline. An additional increase in BrainAGE accumulated to a score of about + 9 years during follow-up. Accelerated brain aging was related to prospective cognitive decline and disease severity. In conclusion, the BrainAGE framework indicates discrepancies in brain aging and could thus serve as an indicator for cognitive functioning in the future.
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