期刊
STRUCTURE
卷 26, 期 1, 页码 145-+出版社
CELL PRESS
DOI: 10.1016/j.str.2017.11.007
关键词
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资金
- IRB
- ICREA
- Obra Social la Caixa
- MINECO [BIO2012-31043, BIO2015-70092-R, BIO2014-53095-P]
- Marato de TV3 [102030, 102031]
- COFUND program of the European Commission
- European Research Council (CONCERT) [648201]
- Ramon y Cajal program of MICINN [RYC-2011-07873]
- Serra Hunter Program
- AGAUR [SGR-2014-56RR14]
- FEDER
- Chief Scientist's Office of the Scottish Government [ETM-258, ETM-382]
- Severo Ochoa Award of Excellence from MINECO (Government of Spain)
- Chief Scientist Office [ETM/382, ETM/258] Funding Source: researchfish
The androgen receptor is a transcription factor that plays a key role in the development of prostate cancer, and its interactions with general transcription regulators are therefore of potential therapeutic interest. The mechanistic basis of these interactions is poorly understood due to the intrinsically disordered nature of the transactivation domain of the androgen receptor and the generally transient nature of the protein-protein interactions that trigger transcription. Here, we identify a motif of the transactivation domain that contributes to transcriptional activity by recruiting the C-terminal domain of subunit 1 of the general transcription regulator TFIIF. These findings provide molecular insights into the regulation of androgen receptor function and suggest strategies for treating castration-resistant prostate cancer.
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