期刊
STRUCTURE
卷 26, 期 8, 页码 1050-1057出版社
CELL PRESS
DOI: 10.1016/j.str.2018.05.009
关键词
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资金
- Klaus Tschira Foundation
- HITS gGmbH
- Max Planck Society
There is renewed interest in linker histone (LH)-nucleosome binding and how LHs influence eukaryotic DNA compaction. For a long time, the goal was to uncover the structure of the chromatosome,'' but recent studies of LH-nucleosome complexes have revealed an ensemble of structures. Notably, the reconstituted LH-nucleosome complexes used in experiments rarely correspond to the sequence combinations present in organisms. For a full understanding of the determinants of the distribution of the chromatosome structural ensemble, studies must include a complete description of the sequences and experimental conditions used, and be designed to enable systematic evaluation of sequence and environmental effects.
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