期刊
NATURE REVIEWS IMMUNOLOGY
卷 12, 期 12, 页码 813-820出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3339
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资金
- US National Institutes of Health
- Broad Medical Research Program of the Eli and Edythe L. Broad Foundation
- Investigator Award from the Cancer Research Institute
- Claudia Adams Barr Award for Innovative Basic Cancer Research
- Dutch Cancer Society
- Dutch MS Research Foundation
- Netherlands Organization for Research
The expression of MHC class I molecules is crucial for the initiation and regulation of adaptive immune responses against pathogens. NOD-, LRR- and CARD-containing 5 (NLRC5) was recently identified as a specific transactivator of MHC class I genes (CITA). NLRC5 and the master regulator for MHC class II genes, class II transactivator (CIITA), interact with similar MHC promoter-bound factors. Here, we provide a broad overview of the molecular mechanisms behind MHC class I transcription and the role of the class I transactivator NLRC5 in MHC class I-dependent immune responses.
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