期刊
EMERGING INFECTIOUS DISEASES
卷 18, 期 12, 页码 1976-1982出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid1812.120498
关键词
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资金
- US Department of Defense Armed Forces Health Surveillance Center, Division of Global Emerging Infections, Surveillance Operations
- Defense Threat Reduction Agency Cooperative Biological Engagement Program ((DTRA-CBEP)
- Google.org
- Skoll Foundation
- U.S. Agency for International Development (USAID) Emerging Pandemic Threats Program, PREDICT project [GHN-A-OO-09-00010-00]
Although the origin of hepatitis C virus infections in humans remains undetermined, a close homolog of this virus, termed canine hepacivirus (CHV) and found in respiratory secretions of dogs, provides evidence for a wider distribution of hepaciviruses in mammals. We determined frequencies of active infection among dogs and other mammals in the United Kingdom. Samples from dogs (46 respiratory, 99 plasma, 45 autopsy samples) were CHV negative by PCR. Screening of 362 samples from cats, horses, donkeys, rodents, and pigs identified 3 (2%) positive samples from 142 horses. These samples were genetically divergent from CHV and nonprimate hepaciviruses that horses were infected with during 2012 in New York state, USA. Investigation of infected horses demonstrated nonprimate hepacivirus persistence, high viral loads in plasma (10(5)-10(7) RNA copies/mL), and liver function test results usually within reference ranges, although several values ranged from high normal to mildly elevated. Disease associations and host range of nonprimate hepaciviruses warrant further investigation.
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