期刊
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
卷 21, 期 5, 页码 443-452出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10253890.2018.1438405
关键词
Anxiety; rearing; open field; context; stress
资金
- University of Zurich Forschungskredit [FK-15-035]
- Olga Mayenfisch Foundation
- Novartis Foundation for Medical Biological Research [10.13039/100004336]
- Betty and David Koetser Foundation for Brain Research
- EMDO-Foundation [10.13039/501100008464]
- Vontobel Foundation
Stressful experiences are linked to anxiety disorders in humans. Similar effects are observed in rodent models, where anxiety is often measured in classic conflict tests such as the open-field test. Spontaneous rearing behavior, in which rodents stand on their hind legs to explore, can also be observed in this test yet is often ignored. We define two forms of rearing, supported rearing (in which the animal rears against the walls of the arena) and unsupported rearing (in which the animal rears without contacting the walls of the arena). Using an automated open-field test, we show that both rearing behaviors appear to be strongly context dependent and show clear sex differences, with females rearing less than males. We show that unsupported rearing is sensitive to acute stress, and is reduced under more averse testing conditions. Repeated testing and handling procedures lead to changes in several parameters over varying test sessions, yet unsupported rearing appears to be rather stable within a given animal. Rearing behaviors could therefore provide an additional measure of anxiety in rodents relevant for behavioral studies, as they appear to be highly sensitive to context and may be used in repeated testing designs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据