期刊
KIDNEY RESEARCH AND CLINICAL PRACTICE
卷 31, 期 4, 页码 249-252出版社
ELSEVIER INC
DOI: 10.1016/j.krcp.2012.09.007
关键词
Acute kidneyinjury; Calcium oxalate; Ethylene glycol; Metabolic acidosis
Ethylene glycol (EG) is a sweet-tasting, odorless organic solvent found in many agents, such as anti-freeze. EG is composed of four organic acids: glycoaldehyde, glycolic acid, glyoxylic acid and oxalic acid in vivo. These metabolites are cellular toxins that can cause cardio-pulmonary failure, life-threatening metabolic acidosis, central nervous system depression, and kidney injury. Oxalic acid is the end product of EG, which can precipitate to crystals of calcium oxalate monohydrate in the tubular lumen and has been linked to acute kidney injury. We report a case of EG-induced oxalate nephropathy, with the diagnosis confirmed by kidney biopsy, which showed acute tubular injury of the kidneys with extensive intracellular and intraluminal calcium oxalate monohydrate crystal depositions. (C) 2012. The Korean Society of Nephrology. PublishedbyElsevier.
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