期刊
STEROIDS
卷 138, 期 -, 页码 14-20出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2018.06.002
关键词
Cross-cyclomagnesiation; Grignard reagents; Steroid oximes; 5Z,9Z-Dienoic acids; Anticancer activity
资金
- Russian Science Foundation [16-13-10172]
- Russian Foundation for Basic Research [16-03-00543_A]
- RF [Sci. Sh. - 5240.2018.3]
- Russian Science Foundation
- Russian Science Foundation [16-13-10172] Funding Source: Russian Science Foundation
Synthetic analogues of natural 5Z,9Z-dienoic acids - hybrid molecules based on the oximes of cholesterol, pregnenolone, and androsterone with 1,14-tetradeca-5Z,9Z-dienedicarboxylic acid - were synthesized for the first time and studied for antitumor activity in vitro. The acid was prepared using catalytic cyclomagnesiation of O-containing 1,2-dienes with Grignard reagent in the presence of Cp2TiCl2 as the key step. Using flow cytometry, it was shown for the first time that the new molecules are efficient apoptosis inducers in the HeLa, Hek293, U937, Jurkat, and K562.
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