期刊
STEM CELLS
卷 36, 期 4, 页码 482-500出版社
WILEY
DOI: 10.1002/stem.2778
关键词
Stem cell-based therapy; Optimized strategies; Secretomes; Exosomes; Ischemic heart diseases
资金
- Science and Technology Department of Zhejiang Province Public Welfare Project [2014C33190]
- National Basic Research Program of China (973 Program) [2014CB965100, 2014CB965103]
- Fundamental Research Funds for the Central Universities [2016XZZX002-03, 2016FZA7005]
- National Natural Science Foundation of China [81670261, 81770484, 81370247, 31371498, 81622006, 81320108003, 31101052]
Ischemic heart diseases (IHDs) remain major public health problems with high rates of morbidity and mortality worldwide. Despite significant advances, current therapeutic approaches are unable to rescue the extensive and irreversible loss of cardiomyocytes caused by severe ischemia. Over the past 16 years, stem cell-based therapy has been recognized as an innovative strategy for cardiac repair/regeneration and functional recovery after IHDs. Although substantial preclinical animal studies using a variety of stem/progenitor cells have shown promising results, there is a tremendous degree of skepticism in the clinical community as many stem cell trials do not confer any beneficial effects. How to accelerate stem cell-based therapy toward successful clinical application attracts considerate attention. However, many important issues need to be fully addressed. In this Review, we have described and compared the effects of different types of stem cells with their dose, delivery routes, and timing that have been routinely tested in recent preclinical and clinical findings. We have also discussed the potential mechanisms of action of stem cells, and explored the role and underlying regulatory components of stem cell-derived secretomes/exosomes in myocardial repair. Furthermore, we have critically reviewed the different strategies for optimizing both donor stem cells and the target cardiac microenvironments to enhance the engraftment and efficacy of stem cells, highlighting their clinical translatability and potential limitation.
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