期刊
STEM CELL RESEARCH
卷 31, 期 -, 页码 157-160出版社
ELSEVIER
DOI: 10.1016/j.scr.2018.07.001
关键词
-
资金
- NCI NIH HHS [K08 CA184418, T32 CA128583] Funding Source: Medline
Juvenile myelomonocytic leukemia (JMML) is a rare myeloproliferative disorder of early childhood characterized by expansion of clonal myelomonocytic cells and hyperactive Ras/MAPK signaling. The disorder is caused by somatic and/or germline mutations in genes involved in the Ras/MAPK and JAK/STAT signaling pathways, including CBL. Here we describe the generation of an iPSC line with a homozygous CBL c.1111T- > C (Y371H) mutation, designated CHOPJMML1854.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据