期刊
STEM CELL RESEARCH
卷 30, 期 -, 页码 96-99出版社
ELSEVIER
DOI: 10.1016/j.scr.2018.05.014
关键词
-
资金
- Suomen Akatemia [301253]
- European Union's Horizon 2020 research and innovation programme [643417]
- Academy of Finland (AKA) [301253, 301253] Funding Source: Academy of Finland (AKA)
An amyloid precursor protein (APP) A673T mutation was found to be protective against Alzheimer's disease (AD) and cognitive decline in the Icelandic population and to associate with decreased levels of plasma beta-amyloid in a Finnish population-based cohort. Human fibroblasts from a Finnish male individual carrying the protective mutation were used to generate integration-free induced pluripotent stem cell (iPSCs) line by Sendai virus technology. The iPSC line retained the mutation and expressed pluripotency markers, had a normal karyotype and differentiated into all three germ layers.
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