期刊
STEM CELL RESEARCH
卷 28, 期 -, 页码 136-140出版社
ELSEVIER
DOI: 10.1016/j.scr.2018.02.005
关键词
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资金
- ERA-NET NEURON (RESPOND)
- European Union [602805]
- Horizon 2020 Research and Innovation Programme [728018]
- 5-100 Russian Academic Excellence Project
- German Research Foundation (DFG) [GZ:TRR58/42016 SFB TRR58-A05]
- University of Wurzburg
Fibroblasts were isolated from a skin biopsy of a clinically diagnosed 51-year-old female attention-deficit/hyperactivity disorder (ADHD) patient carrying a duplication of SLC2A3, a gene encoding neuronal glucose transporter-3 (GLUT3). Patient fibroblasts were infected with Sendai virus, a single-stranded RNA virus, to generate transgene-free human induced pluripotent stem cells (iPSCs). SLC2A3-D2-iPSCs showed expression of pluripotency-associated markers, were able to differentiate into cells of the three germ layers in vitro and had a normal female karyotype. This in vitro cellular model can be used to study the role of risk genes in the pathogenesis of ADHD, in a patient-specific manner. (c) 2018 Published by Elsevier B.V.
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