期刊
SOUTH AFRICAN JOURNAL OF BOTANY
卷 117, 期 -, 页码 79-82出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.sajb.2018.04.003
关键词
Centratherum punctatum; Antibacterial; Synergy; Centratherin; Beta-lactam resistance
资金
- University of KwaZulu-Natal
Three known sesquiterpene lactones were isolated from Centratherum punctatum leaf extract. Their antibacterial properties and synergistic effects with ampicillin against drug-resistant Gram-negative bacteria were studied. Individually, they exerted little or no antibacterial activity against the bacterial strains. However, when combined with ampicillin, centratherin showed synergistic interaction against both bacterial strains. Centratherin reduced the MIC of ampicillin sixteen-fold. It portrayed potentiating effects when combined with the antibiotics. (C) 2018 SAAB. Published by Elsevier B.V. All rights reserved.
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