期刊
SOFT MATTER
卷 14, 期 18, 页码 3632-3639出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/C7SM02452E
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资金
- European Research Council [648050]
- MIUR through PON Research and Competitiveness
We study a variant of a recently proposed non-equilibrium stochastic model for supercoiling-dependent transcription in DNA. In the case of a circular DNA molecule with overall positive supercoiling, we find a non-equilibrium phase transition between an absorbing phase, where all genes are switched off due to the supercoiling, and an active phase with a non-zero transcription rate. Mean field theory predicts that the transition should be continuous at a critical value of the background supercoiling, and we focus our analysis on this case. Our simulations suggest that the switch between the transcribed and silent phases may actually be a fluctuation-induced discontinuous transition, where the jump in the transcription rate decreases with the number of genes in the system.
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