期刊
SOFT MATTER
卷 14, 期 19, 页码 3955-3962出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8sm00112j
关键词
-
类别
资金
- Spanish Ministry of Economy, Industry and Competitiveness through the Severo Ochoa Programme for Centers of Excellence in RD [SEV-2015-0496]
- Spanish Ministry of Economy, Industry and Competitiveness [MAT2015-64442-R]
- Generalitat de Catalunya [2017SGR765]
- ERC Starting Grant [337077-DropCellArray]
- Helmholtz Association's Initiative and Networking Fund [VH-NG-621]
Bacteria can produce cellulose, one of the most abundant biopolymer on earth, and emerge as an interesting candidate to fabricate advanced materials. Cellulose produced by Komagataeibacter Xylinus, a bacterial strain, is a pure water insoluble biopolymer, without hemicellulose or lignin. Bacterial cellulose (BC) exhibits a nanofibrous porous network microstructure with high strength, low density and high biocompatibility and it has been proposed as cell scaffold and wound healing material. The formation of three dimensional (3D) cellulose self-standing structures is not simple. It either involves complex multi-step synthetic procedures or uses chemical methods to dissolve cellulose and remold it. Here we present an in situ single-step method to produce self-standing 3D-BC structures with controllable wall thickness, size and geometry in a reproducible manner. Parameters such as hydrophobicity of the surfaces, volume of the inoculum and time of culture define the resulting 3D-BC structures. Hollow spheres and convex domes can be easily obtained by changing the surface wettability. The potential of these structures as a 3D cell scaffold is exemplified supporting the growth of mouse embryonic stem cells within a hollow spherical BC structure, indicating its biocompatibility and future prospective.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据