期刊
NATURE REVIEWS IMMUNOLOGY
卷 12, 期 12, 页码 858-U76出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3342
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资金
- Institut Pasteur, INSERM
- Fondation pour la Recherche Medicale
- European Research Council
Ten years ago, in 2002, the introduction of dynamic in vivo imaging to immunologists set a new standard for studying immune responses. In particular, two-photon imaging has provided tremendous insights into immune cell dynamics in various contexts, including infection, cancer, transplantation and autoimmunity. Whereas initial studies were restricted to the migration of and interactions between immune cells, recent advances are bringing intravital imaging to a new level in which cell dynamics and function can be investigated simultaneously. These exciting developments further broaden the applications of immunoimaging and provide unprecedented opportunities to probe and decode immune cell communication in situ.
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