期刊
IEEE SENSORS JOURNAL
卷 15, 期 12, 页码 6791-6796出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSEN.2015.2464675
关键词
Biosensor; surface plasmon resonance (SPR); metal nano-particles; plasmon coupling
In this paper, we demonstrate bio-sensing response of bio-medically relevant proteins by employing a surface plasmon resonance (SPR)-based experimental setup that uses a set of double prisms in Kretschmann configuration. The SPR signal of nanoscale Ag-films of varying thicknesses was first monitored experimentally and then verified through computational simulation. The SPR signal was found to be substantially modulated at the metal-dielectric interface when the nanoscale Ag-films are exposed to bio-molecules, such as catalase, papain, bovine serum albumin, trypsin, and lysozyme, which were evaluated independently.
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