期刊
SMALL
卷 14, 期 12, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201703334
关键词
microfluidics; perspiration; super absorbent polymer; sweat chloride
类别
资金
- Air Force Research Laboratory (AFRL) Human Signatures Branch [FA8650-14-D-6516]
- Industrial Strategic Technology Development Program - Ministry of Trade, Industry and Energy (MI, Korea) [10051513]
- NSF [1400169, 1534120, 1635443]
- NIH [R01EB019337]
- Ryan Fellowship
- Northwestern University International Institute for Nanotechnology
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB019337] Funding Source: NIH RePORTER
This paper introduces super absorbent polymer valves and colorimetric sensing reagents as enabling components of soft, skin-mounted microfluidic devices designed to capture, store, and chemically analyze sweat released from eccrine glands. The valving technology enables robust means for guiding the flow of sweat from an inlet location into a collection of isolated reservoirs, in a well-defined sequence. Analysis in these reservoirs involves a color responsive indicator of chloride concentration with a formulation tailored to offer stable operation with sensitivity optimized for the relevant physiological range. Evaluations on human subjects with comparisons against ex situ analysis illustrate the practical utility of these advances.
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