期刊
SMALL
卷 14, 期 7, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201702331
关键词
glioma; gold nanoparticles; retro-inverso bradykinin; size-dependent penetration
类别
资金
- National Science Foundation of China [81473148]
- National Key Basic Research Program of China [2013CB932502]
- National Science and Technology Major Project [2012ZX09304004]
- Foundation Program of Key Laboratory of Smart Drug Delivery of the Ministry of Education
Retro-inverso bradykinin (RI-BK) has better metabolic stability and higher affinity for the BK type 2 (B2) receptor, compared with bradykinin. At low doses, RI-BK can selectively enhance the permeability of the blood-brain tumor barrier (BBTB) without harming normal brain tissue. In this study, gold nanoparticles (GNPs) of size ranging from 5 to 90 nm are synthesized to assess the optimal size of nanocarriers that achieves maximum brain accumulation after the treatment of RI-BK. The ability of the GNPs to cross the BBTB is tested in a rat C6 glioma tumor model. The results of inductively coupled plasma-mass spectrometry and transmission electron microscopy indicate that GNPs with size of 70 nm achieve maximum permeability to the glioma. The present study supports the conclusion that RI-BK can enhance the permeability of BBTB and provides fundamental information for further development of nanomedicines or nanoprobes for glioma therapy.
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