期刊
SMALL
卷 14, 期 16, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201800026
关键词
antioxidant effects; aqueous exfoliation; radical oxygen species; ROS scavenging; transition metal dichalcogenides
类别
资金
- Amore-Pacific RD Center
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [NRF-2017R1A2B2008455, NRF-2016R1A2B2016148, NRF-2015R1C1A1A02036670, 2008-0061891]
- Creative Materials Discovery Program on Creative Multilevel Research Center through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2015M3D1A1068062]
- Supercomputing Center/Korea Institute of Science and Technology Information [KSC-2017-C3-0032]
There is an increasing demand for control over the dimensions and functions of transition metal dichalcogenides (TMDs) in aqueous solution toward biological and medical applications. Herein, an approach for the exfoliation and functionalization of TMDs in water via modulation of the hydrophobic interaction between poly(epsilon-caprolactone)-b-poly(ethylene glycol) (PCL-b-PEG) and the basal planes of TMDs is reported. Decreasing the hydrophobic PCL length of PCL-b-PEG from 5000 g mol(-1) (PCL5000) to 460 g mol(-1) (PCL460) significantly increases the exfoliation efficiency of TMD nanosheets because the polymer-TMD hydrophobic interaction becomes dominant over the polymer-polymer interaction. The TMD nanosheets exfoliated by PCL460-b-PEG(5000) (460-WS2, 460-WSe2, 460-MoS2, and 460-MoSe2) show excellent and prolonged scavenging activity for reactive oxygen species (ROS), but each type of TMD displays a different scavenging tendency against hydroxyl, superoxide, and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radicals. A mechanistic study based on electron paramagnetic resonance spectroscopy and density functional theory simulations suggests that radical-mediated oxidation of TMDs and hydrogen transfer from the oxidized TMDs to radicals are crucial steps for ROS scavenging by TMD nanosheets. As-prepared 460-TMDs are able to effectively scavenge ROS in HaCaT human keratinocytes, and also exhibit excellent biocompatibility.
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