期刊
JOURNAL OF ANXIETY DISORDERS
卷 26, 期 8, 页码 833-843出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.janxdis.2012.07.009
关键词
Pharmacotherapy; Anxiety disorders; Antidepressants; Memory consolidation; Psychedelics
资金
- NIMH NIH HHS [R01 MH066347, R34MH087375, R34 MH087375, R01MH066347] Funding Source: Medline
Modern pharmacological treatments for anxiety disorders are safer and more tolerable than they were 30 years ago. Unfortunately, treatment efficacy and duration have not improved in most cases despite a greater understanding of the pathophysiology of anxiety. Moreover, innovative treatments have not reached the Market despite billions of research dollars invested in drug development. In reviewing the literature on current treatments, we argue that evidence-based practice would benefit from better research on the causes of incomplete treatment response as well as the comparative efficacy of drug combinations and sequencing. We also survey two broad approaches to the development of innovative anxiety treatments:the continued development of drugs based on specific neuroreceptors and the pharmacological manipulation of fear-related memory. We highlight directions for future research, as neither of these approaches is ready for routine clinical use. (C) 2012 Elsevier Ltd. All rights reserved.
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