期刊
SEPARATION AND PURIFICATION TECHNOLOGY
卷 203, 期 -, 页码 178-184出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.seppur.2018.04.041
关键词
Tetracycline; Aqueous two-phase system (ATPS); Ionic liquids; Economic analysis; Monte Carlo simulations
资金
- CONACYT [485025]
- CICECO-Aveiro Institute of Materials - national funds through the FCT/MEC [UID/CTM/50011/2013, POCI-010-145-FEDER-007679]
- FEDER under the PT2020 Partnership Agreement
- European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC [337753]
- FAPESP (Sao Paulo Research Foundation Brazil) [2014/16424-7]
Antibiotics are a key pharmaceutical to inhibit growth or kill microorganisms. They represent a profitable market and, in particular, tetracycline has been listed as an essential medicine by the WHO. Therefore it is important to improve their production processes. Recently novel and traditional aqueous two-phase systems for the extraction have been developed with positive results. The present work performs an economic analysis of the production and recovery of tetracycline through the use of several ATPS through bioprocess modeling using specialized software (BioSolve, Biopharm Services Ltd, UK) to determine production costs per gram (CoG/g). First, a virtual model was constructed using published data on the recovery of tetracycline and extended to incorporate uncertainties. To determine how the model behaved, a sensitivity analysis and Monte Carlo simulations were performed. Results showed that ATPS formed by cholinium chloride/K3PO4 was the best option to recover tetracycline, as it had the lowest CoG/g (US$ 672.83/g), offered the highest recovery yield (92.42%), second best sample input capacity (45% of the ATPS composition) and one of the lowest materials contribution to cost. The ionic liquid-based method of ATPS is a promising alternative for recovering tetracycline from fermentation broth.
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