期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 273, 期 -, 页码 264-275出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2018.06.064
关键词
Multispectral fluorescence imaging; Dual drug delivery; Programmed release; Hydrogel-carbon nanotubes; Combination chemotherapy
资金
- National Natural Science Foundation of China [81601595, 81701813]
- Natural Science Foundation of Tianjin, China [16JCYBJC27800, 14JCYBJC17400]
- CAMS Innovation Fund for Medical Sciences [CIFMS 2017-I2M-3-020]
Multispectral fluorescence imaging, from cellular imaging to in vivo imaging, represents a significant advancement for drug delivery research. Tracking mull-drug release using real-time imaging in vivo can reveal the release processes for guiding the design of an ideal drug delivery system to implement combination chemotherapy. Herein, a sustained and programmed drug delivery system was developed based on a PCL-PEG-PCL thermosensitive hydrogel combined with chitosan-multiwalled carbon nanotubes using doxorubicin (DOX) and rhodamine B (RB) as the model drugs. Dual drug delivery was monitored by fluorescence imaging at the cellular level, and in vivo fluorescence signals in nude mice were tracked by a multispectral fluorescence imaging system. The results demonstrated that the release of these two drugs can be dynamically tracked in vitro and in vivo, respectively using fluorescence imaging techniques. After loading onto carbon nanotubes, DOX exerted a significantly slower release rate compared with RB in the hydrogel due to the dual release of DOX. The hydrogel-carbon nanotube delivery system achieved programmed release of DOX and RB, which affirmed that it can be a potential drug delivery system with programmed release for combined administration.
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