期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 270, 期 -, 页码 459-465出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2018.05.017
关键词
Colorimetric probe; Ratiometric fluorescent probe; Hemicyanine dye; Glutathione; Mitochondria
资金
- National Natural Science Foundation of China [21373250, 21673265]
- 973 Program [2014CB932600]
A new water-soluble fluorescent probe 1 based on hemicyanine dye is designed for selective detection of glutathione (GSH). Probe 1 shows a tremendous colorimetric and ratiometric fluorescence response toward GSH with high selectivity over cysteine/homocysteine. After nucleophilic aromatic substitution reaction with GSH, probe 1 undergoes an intramolecular aldimine condensation that leads to forming a ring, which is accompanied by 107 and 41 nm red-shifts in the absorption and fluorescence spectra, respectively. Subsequent experiments in living cells indicate that probe 1 has a good photostability and response to mitochondrial GSH level in a ratiometric manner. (C) 2018 Elsevier B.V. All rights reserved.
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