期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 267, 期 -, 页码 312-319出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2018.04.055
关键词
Bottom-up synthesis; Two-dimensional metal organic framework; nanosheet; Biosensor; Peroxidase mimic; Hypoxanthine
资金
- National Natural Science Foundation of China [21375021]
- Key Project of Fujian Province [2015Y0050]
- Nature Sciences Funding of Fujian Province [2014J06005]
- Independent Research Project of State Key Laboratory of Photocatalysis on Energy and Environment [2014B02]
- Foundation for Scholars of Fuzhou University [XRC-1671, XRC-17007]
The amino-functionalized metal organic framework (NH2-Cu-MOF) was fabricated via bottom-up synthesis strategy. Detailed characterization using electron microscopy, X-ray photoelectron spectroscopy and atomic force microscopy demonstrated that the as-synthesized NH2-Cu-MOF was two-dimensional nanosheet (a thin thickness similar to 4.2 nm). Results showed that the as-synthesized NH2-Cu-MOF nanosheet possessed fluorescence property (lambda(em) = 425 nm) as well as peroxidase mimic activity. On the basis of these two properties, we proposed a biosensor for hypoxanthine detection. The fluorescence intensity had a linear relationship with the hypoxanthine concentration in the range of 10-2000 mu M. The limit of detection was 3.93 mu M (S/N = 3). This work contributes to the synthesis of a new two-dimensional MOF nanosheet and extends the application of two-dimensional MOF nanosheet on biological luminescent sensors. (C) 2018 Elsevier B.V. All rights reserved.
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