期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 261, 期 -, 页码 418-424出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2018.01.126
关键词
Near-infrared; Fluorescent probe; Hydrazine; Tissue imaging; In vivo imaging
资金
- National Natural Science Foundation of China [NSFC 21572177, 21673173]
- Shaanxi Provincial Natural Science Fund Project [2015JZ003, 2016JZ004]
- Xi'an City Science and Technology Project [2017085CG/RC048(XBDX004)]
Hydrazine has been identified as an environmental contaminant and a probable human carcinogen for its high toxicity. Thus, the development of detection methods for mapping hydrazine in solution and biosystems, particularly in vivo, is of great significance. Here, through firstly exploited 2-thiophenecarbonyl moiety as a recognition unit for hydrazine, a novel near-infrared (NIR) fluorescent probe CyOS is obtained based on hemicyanine. The probe shows high selectivity towards hydrazine over various amino acids and common ions with a significant fluorescence enhancement at 701 nm in the presence of hydrazine. Further, it has a sufficiently low detection limit (0.78 ppb). And most importantly, due to its good cell membrane permeability and low cytotoxicity, CyOS has been applied to monitor and image hydrazine in living cells, tissues and mice. To the best of our knowledge, it is the first time to visualize hydrazine in deep living tissues (similar to 90 mu m). (C) 2018 Elsevier B.V. All rights reserved.
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