期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 257, 期 -, 页码 382-388出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2017.10.181
关键词
Surface-enhanced Raman scattering; Nanoparticles; Electrokinetics; Chemometrics; Principal component analysis; Support vector machines
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- NSERC Vanier Canada Graduate Scholarship
- Ontario Graduate Scholarship
In this paper, we demonstrate rapid, sensitive and specific detection of illicit drugs in both aqueous samples and saliva using surface-enhanced Raman scattering (SERS) substrates with a unique, dendritic architecture. The substrates are prepared on a reusable microelectrode platform by electrokinetically assembling colloidal silver nanoparticles from a droplet. Identification and quantification of illicit drugs is accomplished on these substrates with the aid of Principal Component Analysis (PCA) coupled with a Support Vector Machine (SVM). We demonstrate 100% accuracy in the detection of four different illicit drugs (cocaine, heroin, THC, and oxycodone), and 98.3% accuracy in the quantification of cocaine across four orders of magnitude. Finally, we demonstrate a simple method, with limited sample processing, for the ultrasensitive detection of cocaine in saliva to a limit of detection of 100 ppb. (c) 2017 Elsevier B.V. All rights reserved.
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