Layered assembly of NiMn-layered double hydroxide on graphene oxide for enhanced non-enzymatic sugars and hydrogen peroxide detection

Metal-based non-enzymatic sensors have been intensively explored for rapid and efficient detection of biological molecules. Here, we demonstrate the facile assembly of NiMn-layered double hydroxide (NiMn-LDH) on graphene oxide (GO) (NiMn-LDH/GO) for sugars and hydrogen peroxide (H2O2) monitoring. The hybrids can be easily and large-scale prepared via a simple co-precipitation and hydrothermal approach. Under optimal preparation conditions, NiMn-LDH/GO hybrids exhibit a remarkable sensitivity for glucose oxidation (839.2 mu A mM(-1) cm(-2)) and H2O2 reduction (96.82 mu A mM(-1) cm(-2)), along with a low detection limit of 1.2 mu M and 4.4 mu M, respectively. With regard to glucose detection, the linear response range covered four orders of magnitude from 2 mu M to 3.386 mM with a correlation coefficient of 0.998. Such versatile sensor is also suitable for detecting other sugars (sucrose, mannitol and erythritol). The delicate non-enzymatic sensor possessed rapid response (reach to ready-state in less than 10s), good selectivity and reproducibility toward sugars and H2O2 detection, which will boost the exploration of layered metallic nanomaterials in electrochemical sensors. (c) 2018 Elsevier B.V. All rights reserved.