期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 255, 期 -, 页码 2378-2383出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2017.09.042
关键词
Fluorescent probes; Hypochlorite; Recognition mechanism; Aldehyde group; Bioimaging
资金
- National Natural Science Foundation of China [21672131, 21775096, 21705102]
- Talents Support Program of Shanxi Province [2014401]
- Shanxi Province Foundation for Returness [2017-026]
- Shanxi Province Science Foundation for Youths [201701D221061]
- Scientific Instrument Center of Shanxi University
In this study, we have developed two fluorescent probes for hypochlorite based on a novel recognition mechanism: aldehyde group oxidized into carboxyl group by sodium hypochlorite. The new mechanism was proved by H-1 NMR, C-13 NMR and ESI-MS analysis for their reacting products. UV-vis and fluorescence titration spectra for ClO- were investigated in PBS (pH 7.4). The detection limits of probe 1 and probe 2 were found to be as low as 77.82 nM and 61.14 nM, respectively. Furthermore, the probes could be used to monitor intracellular ClO- in RAW264.7 macrophage cells. (C) 2017 Elsevier B.V. All rights reserved.
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