期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 266, 期 -, 页码 528-533出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2018.03.162
关键词
Benzothiadiazole derivatives; Glutathione detection; Fluorescent turn-on sensor; Smiles rearrangement; Bioimaging
资金
- National Natural Science Foundation of China (NSFC) [21602051, 21676075, 21503073]
- Natural Science Foundation of Hubei Province [2016CFB200]
Biothiols, such as glutathione (GSH), cysteine (Cys), homocysteine (Hcy), plays crucial roles in biological systems due to their physiological and pathological functions. So it is of great interest to develop new fluorescence sensing systems for distinguishing between them. Herein we report a novel fluorescent turn-on probe for selective sensing of GSH over Cys/Hcy with high selectivity and sensitivity. The sensing behavior of ATD-Cl toward GSH and Cys/Hcy is completely different from most of the previous reported NBD-based fluorescent probes. The detection limit of ATD-Cl for GSH is found to be 89 nM. Cell imaging experiments demonstrate that ATD-Cl possesses excellent cell permeability and can be employed to image GSH in living MCF-7 cells. (C) 2018 Elsevier B.V. All rights reserved.
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