期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 267, 期 -, 页码 502-509出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2018.04.060
关键词
Colorimetric sensor; Au Nanobipyramid@Ag Nanorods; Squamous cell carcinoma antigen; Localized surface plasmon resonance; Absorbance intensity
资金
- Natural Science Foundation of China [21675028, 21575027, 21375021, 51473179, 21575025]
- Key Project of Fujian Province [2015Y0050]
- General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China [2016Ik039]
- Bureau of Science and Technology of Fuqing City
- Youth Innovation Promotion Association of Chinese Academy of Sciences [2016268]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT_15R11]
Common colorimetric immunoassays only show monochromatic intensity variations, and the absorbance intensity is utilized for the quantitative detection of the analytes. Herein, we demonstrate for the first time that Au Nanobipyramid@Ag Nanorods (Au NBP@Ag) is an ideal multicolor chromogenic substrate for immunoassays which combines the absorbance intensity with the Localized Surface Plasmon Resonance (LSPR) peak shifts are utilized for quantitative detection of the analytes, and vivid color variations are used for semi-quantitative detection. Our investigation reveals that unlike the single metallic nanoparticles such as gold nanorods which show one-way LSPR peak shifts, Au NBP@Ag Nanorods shows an interesting multi-way peak shifts: the LSPR peak would initially blue shift, and then red shift, finally blue shift again during the etching process. As a result, a series of vivid colors can be observed. The results indicate that the correlation linear range for the detection of Squamous cell carcinoma antigen (SCCA) was 2.5-105 ng/mL. Although only the detection of SCCA is demonstrated in this work, this method is easy to expand to detect other biomarkers since our method is based on conventional immunoassay strategy. (C) 2018 Elsevier B.V. All rights reserved.
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