期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 257, 期 -, 页码 772-782出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2017.11.018
关键词
N- and P-doped carbon dots; Alendronate sodium; Fluorescence; Uranyl ion detection; Cellular imaging
资金
- Tarbiat Modares University Research Council
- Razi University Research Council
- Iran Science Elites Federation (ISEF)
Innovative water-soluble nitrogen-phosphorus co-doped carbon dots (N,P-CDs) with bright luminescence and high quantum yields of 35.0% were synthesized via a simple and straightforward hydrothermal method, using an aqueous solution of alendronate sodium as a novel N and P containing single-source precursor. UV-vis absorption and photoluminescence spectroscopies, TEM, AFM, X-ray photoelectron spectroscopy, dynamic light scattering and FT-IR spectroscopy were used to characterize the morphological, structural and optical properties of the synthesized N, P-CDs. The N, P-CDs with excellent water solubility and biocompatibility possess a strong greenish blue emission centered at 420 nm(lambda(em) = 330 nm). Due to the existence and special response of bisphosphonate groups to uranyl ions( UO22+), the fluorescence signal of N, P-CDs found to rapidly and selectively quench by this important cation. The linear response range to UO22+ was from 0.01 to 2.5 mu M with a limit of detection of 4.5 nM(S/N = 3). The prepared N, P-CDs was then applied to highly sensitive and selective detection of traces of uranyl ion in water and hair samples. Moreover, the prepared N, P-CDs were used as a nice bioimaging agent in BT474 cells, so that the cytotoxicity and cellular uptake of N, P-CDs were investigated by a MTT assay and through a localization study, respectively. (c) 2017 Elsevier B.V. All rights reserved.
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