期刊
SEMINARS IN IMMUNOLOGY
卷 35, 期 C, 页码 3-11出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2017.12.002
关键词
Dendritic cells; Immune regulation; Innate immunity; Inflammation
类别
资金
- National Natural Science Foundation of China [81701574]
- Key Program of National Natural Science Foundation of China [81730039]
- National 863 Project [SS2014AA020801]
- Shanghai Rising-Star Program [12QA1404100]
- Foundation for the Author of National Excellent Doctoral Dissertation of China [201180]
As potent antigen-presenting cells, dendritic cells (DCs) comprise the most heterogeneous cell population with significant cellular phenotypic and functional plasticity. They form a sentinel network to modulate immune responses, since intrinsic cellular mechanisms and complex external, environmental signals endow DCs with the distinct capacity to induce protective immunity or tolerance to self. Interactions between DCs and other cells of the immune system mediate this response. This interactive response depends on DC maturation status and subtype, as well as the microenvironment of the tissue location and DC-intrinsic regulators. Dysregulated DCs can initiate and perpetuate various immune disorders, which creates attractive therapeutic targets. In this review, we provide a detailed outlook on DC ontogeny and functional specialization. We highlight recent advances on the regulatory role that DCs play in immune responses, the putative molecular regulators that control DC functional responding and the contribution of DCs to inflammatory disease physiopathology.
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