期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 83, 期 -, 页码 42-50出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2018.02.022
关键词
Unconventional secretion; Galectins; Annexins; Transport
资金
- Wellcome Trust Strategic Award [100574/Z/12/Z]
- MRC Metabolic Diseases Unit [MRC_MC_UU_12012/5]
- BBSRC Future Leader Fellowship
- Isaac Newton Trust/Wellcome Trust ISSF/University of Cambridge joint research grant
- Wellcome Trust PhD Studentship
- BBSRC [BB/P010911/1] Funding Source: UKRI
- MRC [MC_UU_12012/5] Funding Source: UKRI
Eukaryotic cells have a highly evolved system of protein secretion, and dysfunction in this pathway is associated with many diseases including cancer, infection, metabolic disease and neurological disorders. Most proteins are secreted using the conventional endoplasmic reticulum (ER)/Golgi network and as such, this pathway is well-characterised. However, several cytosolic proteins have now been documented as secreted by unconventional transport pathways. This review focuses on two of these proteins families: annexins and galectins. The extracellular functions of these proteins are well documented, as are associations of their perturbed secretion with several diseases. However, the mechanisms and regulation of their secretion remain poorly characterised, and are discussed in this review. This review is part of a Special Issues of SCDB on 'unconventional protein secretion' edited by Walter Nickel and Catherine Rabouille. (C) 2018 The Authors. Published by Elsevier Ltd.
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