期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 80, 期 -, 页码 74-82出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.07.004
关键词
Regeneration; Apoptosis-induced proliferation; Reactive oxygen species; Macrophages; Drosophila
资金
- National Institute of General Medical Sciences (NIGMS) [R35 GM118330]
Apoptosis-induced compensatory proliferation (AiP) is a form of compensatory proliferation that is triggered by apoptotic cell death to maintain tissue homeostasis. As such, AiP is essential for many tissue repair processes including regeneration. The apoptotic effectors, termed caspases, not only execute apoptosis, but are also directly involved in the generation of the signals required for AiP. Reactive oxygen species (ROS) play an important role for regenerative processes. Recently, it was shown in Drosophila that apoptotic caspases can mediate the generation of ROS for promoting AiP. This review summarizes and discusses these findings in the context of regenerative processes and cancer. (C) 2017 Elsevier Ltd. All rights reserved.
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