期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 89, 期 -, 页码 71-77出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2018.05.023
关键词
Innate immune memory; Monocytes; Fungi; beta-glucan; Disease
资金
- ANR JCJC grant [ANR-16-CE15-0014-01]
- Institut Carnot Pasteur MI grant [ANR 11-CARN 017-01]
- Agence Nationale de la Recherche (ANR) [ANR-16-CE15-0014] Funding Source: Agence Nationale de la Recherche (ANR)
The binary classification of mammalian immune memory is now obsolete. Innate immune cells carry memory characteristics. The overall capacity of innate immune cells to remember and alter their responses is referred as innate immune memory and the induction of a non-specific memory resulting in an enhanced immune status is termed trained immunity. Historically, trained immunity was first described as triggered by the human fungal pathogen Candida albicans. Since, numerous studies have accumulated and deciphered the main characteristics of trained immunity mediated by fungi and fungal components. This review aims at presenting the newly described aspect of memory in innate immunity with an emphasis on the historically fungal mediated one, covering the known molecular mechanisms associated with training. In addition, the review uncovers the numerous non-specific effect that beta-glucans trigger in the context of infectious diseases and septicaemia, inflammatory diseases and cancer. (C) 2018 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据