期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 79, 期 -, 页码 80-91出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.10.006
关键词
Male germline; Testis; RNA processing; Spermatogonia; Germ cells; Post-transcriptional regulation
资金
- Australian Research Council (ARC) Stem Cells Australia Special Research Initiative
- ARC
- State Government of Victoria
- Australian Government
Mammalian spermatogenesis is a tightly coordinated process that gives rise to mature spermatozoa capable of fertilising an ovum during sexual reproduction. A population of stem and progenitor cells known as undifferentiated spermatogonia enables continual spermatogenesis throughout life. A complex transcriptional network that balances self-renewal of spermatogonia with their timely differentiation in order to maintain constant fertility regulates this process. Importantly, post-transcriptional regulation of gene expression plays a critical role in spermatogenesis, necessitated by the profound genetic and morphological changes that occur during meiosis and sperm maturation. Pre-mRNA splicing, mRNA export, maintenance of transcript stability and translation are key RNA processing steps that are regulated in the male germline to maintain coordinated gene expression. In this review, we examine these processes in the context of mammalian spermatogenesis and provide an overview of key mediators at each step. (C) 2017 Elsevier Ltd. All rights reserved.
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