期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 73, 期 -, 页码 4-12出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.07.003
关键词
Atomic force microscopy; Cardiomyocyte; Biomechanical properties; Mechanotransduction; Beating activity
资金
- Fondation Leducq, Transatlantic Network of Excellence (grant number 14-CVD 03). [14-CVD 03]
Cardiovascular diseases (CVDs) are the number one cause of death globally, therefore interest in studying aetiology, hallmarks, progress and therapies for these disorders is constantly growing. Over the last decades, the introduction and development of atomic force microscopy (AFM) technique allowed the study of biological samples at the micro- and nanoscopic level, hence revealing noteworthy details and paving the way for investigations on physiological and pathological conditions at cellular scale. The present work is aimed to collect and review the literature on cardiomyocytes (CMs) studied by AFM, in order to emphasise the numerous potentialities of this approach and provide a platform for researchers in the field of cardiovascular diseases. Original data are also presented to highlight the application of AFM to characterise the viscoelastic properties of CMs. (c) 2017 Elsevier Ltd. All rights reserved.
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